Pastor Brian Miller points out that the average American moves every three years, and many students are currently dealing with moves for education or family reasons. Acts chapter 13 marks a significant shift in the church's focus, with the church in Antioch taking a prominent role in God's work. The pastor emphasizes that the church willingly gives its best and brightest for missionary work, and God calls and commissions missionaries during an exciting time in the church. Additionally, Pastor Brian highlights the importance of facing opposition with confidence and conviction when following God's call, encouraging the congregation to embrace opportunities and obey God's guidance as they navigate the changes and challenges in their lives.